The Genome Center
Assistant Professor, Department of Biology
"On the road to personalized therapy, a systems approach“
Abstract: Systematic characterization of cancer genomes has revealed a staggering complexity of aberrations among individuals, such that the functional importance and physiological impact of most tumor genetic alterations remains poorly defined. A major challenge involves the development of analysis methods to integrate the flood of genome-wide data on tumors towards patient-specific tumor network models. We will elaborate on two computational approaches: (1) Integration of genetic and genomic data to identify genetic determinants of cancer and model how these alter the regulatory network, as well as drug response. (2) Single cell models of cancer signaling based on mass cytometry, a novel technology that can accurately measure more than forty signaling molecules simultaneously single cells. We will demonstrate the utility of these applications of these approaches across a broad range of different cancers.
Monday, March 5, 2012
10:00 a.m., 1005 GBSF Auditorium