Post-Doc Position available in Ecology of Emerging Infectious Disease

Post-Doc Position available in Ecology of Emerging Infectious Disease

The Epicenter for Disease Dynamics at the One Health Institute in the School of Veterinary Medicine at UC Davis is seeking a post-doctoral researcher interested in the impacts of environmental change on the epidemiology, ecology and evolution of zoonotic diseases. Activities will focus on a new National Science Foundation Ecology and Evolution of Infectious Diseases project “Impacts of Rapid Landscape Change and Biodiversity on Virus Host Specificity”.

Primary responsibilities relate to both theoretical and data-informed modeling of virus evolution and transmission across landscape changes in Southeast Asia. This is a 3-year post-doctoral position, expected to begin January 2022 based at UC Davis with opportunities for collaboration and co-mentorship across the PIs on this project including Christine Kreuder Johnson (UCD), Tierra Smiley Evans (UCD), Lark Coffey (UCD), Michael Boots (UC Berkeley), and Rebekah Kading (CSU).

Project Overview:

This study investigates the impacts of deforestation, landscape change, and biodiversity on virus characteristics that determine zoonotic potential, including virus “host plasticity”, which is the diversity of host species a virus can infect in nature. Findings from this research will contribute to ecological theory on the impact of environmental changes on microbial adaptation, with practical implications for management of ecosystems at high risk for pathogen spillover. Investigations will evaluate host range of bat-borne coronaviruses and mosquito- borne arboviruses (flaviviruses, alphaviruses and bunyaviruses) in the biodiverse tropical forests of Southeast Asia. Activities will include theoretical and computational modeling, underpinned by field investigations and in vitro experiments, to develop data and model driven insights into the role that mosquito vectors play in constraining or expanding virus host plasticity and genetic diversity. Characterization of bat-borne coronaviruses and host affinities in an ecosystem with SARS-CoV-related viruses will further inform on coronavirus evolution and emergence of zoonotic potential. This position will conduct research in a team science setting that is especially relevant to development of an evidence-base on the relationship between environmental change, biodiversity, disease outbreaks, and pandemics to underpin public policy.

65% SCIENTIFIC RESEARCH

  • Contribute to designing field studies to investigate virus host plasticity, evolution and transmission across forest gradients in Southeast Asia;
  • Develop methods and analyses to evaluate surveillance strategies to detect zoonotic pathogens at high-risk interfaces for disease emergence;
  • Analyze metadata on emerging zoonotic diseases, high-risk human-animal contact, and ecological risk and conduct data analyses needed to train models for emerging disease prediction;
  • Develop advanced analytical techniques and associated programming capabilities for infectious disease modeling, predictive frameworks, and social network analyses;
  • Conduct independent research and produce high quality scientific manuscripts related to biosurveillance and the ecology of emerging infectious disease.

35% PROJECT IMPLEMENTATION

  • Provide disease expertise, technical support, data analyses, and data-sharing tools for zoonotic disease prediction and biosurveillance projects;
  • Provide epidemiologic expertise to field staff in other countries on study design, data collection, data management, data analysis and interpretation, and publication preparation;
  • Contribute to regular summaries of surveillance data, assist in development of data collection and data management tools; and ensure open communication and coordination with international partners in project implementation;
  • Travel to international field sites to work with field staff, participate in field activities, and attend scientific meetings as needed.

Skills needed:

Background in infectious disease epidemiology or disease ecology and strong quantitative skills in biostatistics, epidemiology, and mathematical modeling with knowledge of animal health and wildlife disease. Experience with statistical software including R and STATA, as well as ability to write code for programming, including Python. Experience conducting independent, applied scientific research on infectious diseases with a promising publication track record.

Education:

PhD in biology, ecology, epidemiology, or related life-science (required)

Application:

Please email cover letter and CV by September 30th to:

Tierra Smiley Evans, DVM, PhD and Christine Kreuder Johnson, VMD, PhD EpiCenter for Disease Dynamics | One Health Institute
School of Veterinary Medicine
University of California
Davis, CA 95616
530-752-1238

tsmevans@ucdavis.edu, ckjohnson@ucdavis.edu

NSF EEID_Post_Doc_Position.pdf

New paper from the Eisen lab (with many others) on Global biogeography of chemosynthetic symbionts

Paper: Global biogeography of chemosynthetic symbionts reveals both localized and globally distributed symbiont groups | PNAS

PR from MPG here: Symbionts without borders – Bacterial partners travel the world

Authors:

  • Co-First Authors: Jay T. Osvatic and Laetitia G. E. Wilkins
  • Co-Last Authors: Jillian M. Petersen and Benedict Yuen
  • Other authors: Lukas Leibrecht, Matthieu Leray, Sarah Zauner, Julia Polzin, Yolanda Camacho, Olivier Gros, Jan A. van Gils, Jonathan A. Eisen

Significance (from the paper)

Knowledge of host–symbiont biogeography is critical to understanding fundamental aspects of symbiosis such as host–symbiont specificity. Marine animals typically acquire their symbionts from the environment, a strategy that enables the host to associate with symbionts that are well-suited to local conditions. In contrast, we discovered that in the chemosymbiotic bivalve family Lucinidae several host species distributed across the globe are all associated with a single cosmopolitan bacterial symbiont. The genetic cohesiveness of this global symbiont species is maintained through homologous recombination across its extensive geographical range. The remarkable flexibility in the lucinid association is advantageous to both host and symbiont as it increases the likelihood of locating a compatible partner across diverse habitats spanning the globe.

Abstract (from the paper)
 

In the ocean, most hosts acquire their symbionts from the environment. Due to the immense spatial scales involved, our understanding of the biogeography of hosts and symbionts in marine systems is patchy, although this knowledge is essential for understanding fundamental aspects of symbiosis such as host–symbiont specificity and evolution. Lucinidae is the most species-rich and widely distributed family of marine bivalves hosting autotrophic bacterial endosymbionts. Previous molecular surveys identified location-specific symbiont types that “promiscuously” form associations with multiple divergent cooccurring host species. This flexibility of host–microbe pairings is thought to underpin their global success, as it allows hosts to form associations with locally adapted symbionts. We used metagenomics to investigate the biodiversity, functional variability, and genetic exchange among the endosymbionts of 12 lucinid host species from across the globe. We report a cosmopolitan symbiont species, Candidatus Thiodiazotropha taylori, associated with multiple lucinid host species. Ca. T. taylori has achieved more success at dispersal and establishing symbioses with lucinids than any other symbiont described thus far. This discovery challenges our understanding of symbiont dispersal and location-specific colonization and suggests both symbiont and host flexibility underpin the ecological and evolutionary success of the lucinid symbiosis.

Acknowledgements (from the paper)

We thank Gustav Paulay (FLMNH, Gainesville, FL), Amanda Bemis, and John Taylor (NHM, London) for providing preserved samples. John Taylor also provided high-resolution images of lucinid clams for Fig. 2. We thank Liz Hambleton (University of Vienna), Miriam Weber, Christian Lott, Boris Unger, Dorothée Makarow, Natalie Elisabeth (University of California, Berkeley), Diana Chin, Tim Oortwijn, and Arthur Curry for providing fresh samples. We also thank Thalassa for 300 million y of sheltering lucinids. We are grateful to Stephanie Markert for providing access to the proteomics data, Ipek Yamin Meric and Nora Grossschmidt for helping with DNA extractions, Marina DeLeón for help with fieldwork and travels in Costa Rica, Cassandra Ettinger for early discussions of the study, and Guillaume Jospin for support with the bioinformatic analyses. We thank Xavier Didelot for discussions on the recombination analysis. L.G.E.W. was supported by Grant GMBF5603 from the Gordon and Betty Moore Foundation (J.A.E. was Principal Investigator on the same grant). The work was also supported by the European Research Council Starting Grant EvoLucin and a Vienna Research Grant for Young Investigators from the Vienna Science and Technology Fund (WWTF, VRG14–021) and the Austrian Academy of Sciences. Sequencing was carried out at the DNA Technologies and Expression Analysis Cores at the University of California, Davis Genome Center (supported by NIH Shared Instrumentation Grant 1S10OD010786-01), the Biomedical Sequencing Facility at CeMM (https://www.biomedical-sequencing.org/) in Vienna, Austria, and at the Joint Microbiome Facility (JMF) of the Medical University of Vienna and the University of Vienna (project ID 1911-1). Thanks to Petra Pjevac and Gudrun Kohl for sample processing at JMF. The gill embedding was performed by the Histopathology Facility at Vienna BioCenter Core Facilities, a member of the Vienna BioCenter, Austria.

Funding: Gordon and Betty Moore Foundation (for the part from my lab at least). Part of a collaboration with STRI.

News Stories about air filter testing for SARS-CoV-2 in Davis, CA schools

David Coil has been coordinating a project to do air filter testing for Sars-CoV-2 in Davis, CA schools in collaboration with Heather Bischel, Karen Shapiro, Roque G Guerrero, Randi Pechacek, and others. This has been supported by the Healthy Davis Together project.

Recently there have been a few news stories about this work and I thought I would post some links here.

KCRA: Here’s the new way COVID-19 testing is happening at 2 Davis schools

Woodland Daily Democrat: Davis Joint Unified School District prepares against COVID-19 with air filters

Also see UC Davis Live on this topic: https://www.ucdavis.edu/news/media-advisory-uc-davis-live-back-to-school-safely

And see the Healthy Davis Together page on this: https://healthydavistogether.org/airfiltertesting/

New collaborative paper out: Air versus Water Chilling of Chicken: a Pilot Study of Quality, Shelf-Life, Microbial Ecology, and Economics 

A new paper is out from the lab from a large collaboration between UC Davis and Colorado State University.

See: Air versus Water Chilling of Chicken: a Pilot Study of Quality, Shelf-Life, Microbial Ecology, and Economics | mSystems

This was supported by a grant from the UC Davis Innovation Institute for Food and Health.

 

New preprint from the lab (in a collaboration with many others at UC Davis): SARS-CoV-2 detection and genomic sequencing from hospital surface samples collected at UC Davis

My lab has been involved in a collaboration with many others at UC Davis on studying SARS-CoV2 in surface samples from the UC Davis hospital. A preprint of a paper on this topic has been posted to medRxiv with David Coil as the first author.  See: SARS-CoV-2 detection and genomic sequencing from hospital surface samples collected at UC Davis | medRxiv

 

New article out from the Eisen Lab: Isolation and sequence-based characterization of a koala symbiont: Lonepinella koalarum

See Isolation and sequence-based characterization of a koala symbiont: Lonepinella koalarum

Paper based on PhD thesis work of Katie Dahlhausen and wrap up of analysis led by Laetitia Wilkins.

Full citation:

Dahlhausen KE, Jospin G, Coil DA, Eisen JA, Wilkins LGE. 2020. Isolation and sequence-based characterization of a koala symbiont: Lonepinella koalarum. PeerJ8:e10177 https://doi.org/10.7717/peerj.10177

Acknowledgements. We thank Céline Caseys ORCID: 0000-0003-4187-9018 for her idea to search eggNOG annotations against KEGG Class 1.11 Xenobiotics biodegradation and metabolism pathways; Chris Brown ORCID: 0000-0002-7758-6447 for his script to download assemblies in batch from GenBank; Cassandra L. Ettinger ORCID: 0000-0001-7334-403X for valuable comments on the pangenome analysis and help with revising the figures. We also thank Dr. Joseph Gillespie ORCID: 0000-0002-5447-7264, Dr. Raphael Eisenhofer ORCID: 0000-0002-3843-0749 and two anonymous reviewers for comments on the submitted manuscript. Isolate 16S Sanger sequencing was performed at the UC Davis College of Biological Sciences DNA Sequencing Facility.

TODAY at @ucdavis – Clarissa Nobile on “Candida albicans biofilms: Importance, regulation, and a serendipitous discovery”

TODAY:

MIC 291: Selected Topics in Microbiology

Work-in-Progress Seminars

Associate Professor Clarissa Nobile

UC Merced

Molecular & Cell Biology

Candida albicans biofilms: Importance, regulation, and a serendipitous discovery”

Wednesday, February 19, 2020

4:10 pm

1022 Life Sciences

Clarissa Nobile flyer, Feb 19 2020.pdf

Valentine’s day is for the microbiome: at @ucdavis 2/14 – Peter Turnbaugh “”Eating for Two Trillion: Reciprocal Interactions between Diet and the Human Gut Microbiome”

Peter Turnbaugh, Ph.D.,
MMI 291 Seminar Series,
Friday, February 14, 2020.
"Eating for Two Trillion: Reciprocal Interactions between Diet and the Human Gut Microbiome”
12:10 pm
GBSF 1005.

Tomorrow at @ucdavis Corrie Moreau “Piecing Together the Puzzle to Understand the Evolution of the Ants: Macroevolution to Microbiomes”

This weeks Entomology and Nematology Seminar:

Dr. Corrie Moreau
Cornell University

"Piecing Together the Puzzle to Understand the Evolution of the Ants: Macroevolution to Microbiomes"

Briggs 122 at 4:10PM, Wednesday January 15, 2020

A summary from her lab website:

Research in our lab focuses on the symbiotic factors that drive speciation, adaptation, and evolutionary diversification. We use ants and other insects to tease apart the factors that influence patterns of evolution – from the rise of the flowering plants, symbioses ants have with other insects and plants, and their gut-associated microbial community are all potential underlying factors that may have facilitated their ecological dominance in almost all terrestrial ecosystems.

More at her website:
Moreau lab

1/13 at @ucdavis: Justice Mariano-Florentino Cuéllar

Posting this email I received about an interesting talk on January 13.

Ironically, I have jury duty that AM so not sure if I can make it.

————–

Dear Davis Community,

This coming Monday, January 13th, California Supreme Court Justice Mariano-Florentino Cuéllar will join The UC Davis Forums on the Public University and the Social Good in conversation regarding the legal implications of the challenges facing higher education today.

In this wide-ranging discussion moderated by Associate Vice Chancellor for Academic Diversity Raquel Aldana, Justice Cuéllar will speak on the legal implications of the challenges facing higher education today. In light of recent national discussions over such issues as admissions policies and practices, Statements on Contributions to Diversity and Equity, immigration policies, and DACA, Justice Cuéllar will address how UC Davis might remain a leader in setting current policies and practices that are both true to its mission and legally defensible. Taking the long view from his years of experience working on issues of equity and excellence, Justice Cuéllar is in a unique position to reflect on the import of college access in the context of the California Master Plan for Higher Education.

 

This conversation-style Forum will take place Monday, January 13th, 2020 in the Multipurpose Room (2nd Floor) of the Student Community Center. The Forum is from 3 to 4:30 PM with a reception to follow.

Please RSVP on our Eventbrite page here.

For more information about this Forum, please visit the links or view the flyer below.

We look forward to seeing you there.

forums.ucdavis.edu

facebook./com/ucdavisforums

ucdavisforums.eventbrite.com