Paper of interest: Whole genome and exome sequencing of monozygotic twins discordant for Crohn’s disease

For those interested in microbiomes it is definitely worth looking at this paper: BMC Genomics | Abstract | Whole genome and exome sequencing of monozygotic twins discordant for Crohn’s disease

Simple summary – they have sets of identical twins where one twin has Crohn’s and the other does not.  They looked for somatic mutations that could like the ones with Crohn’s and did not find any.  Sure – a negative result.  Could be anything.  But the next obvious thing to do (which they report they are already doing) is to look at the microbioata in these people.  Alas, they probably do not have data from before these people got Crohn’s, but still, this could be interesting …

About Jonathan Eisen

I am an evolutionary biologist and a Professor at U. C. Davis. (see my lab site here). My research focuses on the origin of novelty (how new processes and functions originate). To study this I focus on sequencing and analyzing genomes of organisms, especially microbes and using phylogenomic analysis

One thought on “Paper of interest: Whole genome and exome sequencing of monozygotic twins discordant for Crohn’s disease

  1. I wonder if its worth looking at different tissues in cases like these? Could there also be changes in specific tissues? If there is somatic mosaicism between twins there may be somatic mosasicism within one person…..

    Like

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s