University of California, Davis
Department of Microbiology & Molecular Genetics
College of Biological Sciences
MIC 291: Selected Topics in Microbiology
Work-in-Progress Seminars
Dr. Robert Edgar
(Independent scientist and consultant in fields of computational biology and bioinformatics)
“Sequence analysis for marker gene metagenomics”
Wednesday, March 30, 2016
4:10pm
1022 Life Sciences
Abstract: Microbial community studies using marker genes such as 16S and ITS present challenging sequence analysis problems due to sparse coverage in reference databases and the difficulty in distinguishing experimental error from true biological variation. I will show that several popular algorithms for taxonomy prediction and for creating de novo clusters (OTUs) have high error rates, and describe new algorithms with greatly improved accuracy.
Dr. Edgar is best known for developing the widely-used MUSCLE and USEARCH programs, which have been cited by thousands of published papers. He also works as a consultant and looks for opportunities to leverage his unique combination of business and scientific skills by helping start-up companies.
Host: Prof. Mitch Singer (mhsinger)
Department of Microbiology & Molecular Genetics
(note – title uses a definition of metagenomics that I do not endorse …)
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