Lab meeting at Yolo Basin – science should be fun …

Was both a very good and a very bad day yesterday.  I will leave out the bad here other than to say that a close relative was diagnosed with a very bad cancer.  Fortunately, I had already planned to have my lab meeting (in picnic format) out at Yolo Basin Wildlife area and so I had to soldier on.  I scouted out the Yolo Basin in the early AM (after dropping my mom off at the airport).  And during the scouting trip I saw all sorts of cool wildlife.  Some of the pics are below:

Coyote hunting rodents off in the distance

Ring necked pheasant

And then I headed on over to where we were going to have the picnic (to make sure they were not doing any construction work near there as I had seen trucks there a few days before).  And on the way to the parking lot I saw some otter poop in the road.  It seemed very very fresh.  So I slowed down (to even less than the 15 MPH I was going) and then I saw them.

Two otters.  Just a few feet in front of me.  Playing.  They eyed me suspiciously, and then headed into the little channel.

After a brief swim they headed out on the other side.

And then they eyed me from the safety of the other side and sniffed around, scratched, pooped and did many other things.

And then I guessed they decided it was time to go back in the water.

It seemed like they were egging each other on and then decided to both go in at the same time.

And then they swam around, mostly ignoring me and headed off.

What a wonderful sighting.  And then I headed on out of the park to get some picnic food.  But I went slowly and took some bird pics along the way.  Some very nice lighting as it was still early in the AM.

Lots of avocets, which are very photogenic

And lots of white faced ibises, which, depending on the angle relative to the sun can seem drab or glorious

And a slew of other birds including ducks, herons, etc. Here are some highlights

Breeding colors for egret (see green on nose)

Pelicans

Ruddy duck couple
Ruddy duck couple
And then off to buy food and then back to Yolo Basin to meet up with my lab.  
We had a picnic.  I was too distracted to take too many pics.  Here are some I took. Will try to post some from people in the lab too.

and then went for a hike.  Didn’t take too many pictures of that but here are some.  Good that 

Otter prints

Black shouldered kite
And then headed out, not before taking some more pics on the way such as this one

Oh and of course, there was some chatter on Twitter about lab meeting … see the Storify here.

And in response to some comments on Twitter – here are a few pics with plants featured. Mostly, I note, I was focusing on animals because I had my telephoto lens on the camera and did not switch until the very end of the day to a macro lens.

Today at 4 at #UCDavis: Jonathan Pritchard on “Interpreting functional consequences of human genetic variation”

Jonathan Pritchard is will be giving the Ecology and Evolution seminar today on “Interpreting functional consequences of human genetic variation.”4:10-5:30PM; in 176 Everson Hall.

Jonathan’s work addresses basic questions in evolutionary biology and genomics using computational and statistical approaches.

From his website:
“Much of our work focuses on questions relating to genetic variation and evolution. What can we learn from DNA sequence data about population structure, population histories and natural selection? How does genetic variation impact phenotypic traits, both at the organismal and cellular level (including an emphasis on gene regulation)? ”
http://pritchardlab.stanford.edu/home.html

Right to be forgotten bill has grave implications for science

Yes, the web can be a quagmire of inaccurate, offensive libelous crap.  But wow – this new ruling about the “right to be forgotten bill” in Europe I think goes too far (e.g., see this story for more info on the bill Google gets ‘right to be forgotten’ requests hours after EU ruling – Telegraph).  (Quick summary – the ruling basically says that people have the right to request that search engines make it impossible to access   certain links – such as ones to stories the requestor does not like).

I am particularly concerned about how this bill will affect scientific discourse.  Suppose for example that Andrew Wakefield wants criticism of his fraduelent work on vaccines to be expunged from the links that come up in Google searches?  What should Google do there?  What about retracted papers in general?  What is the person behind the paper does not think that retracted papers should appear in searches for that person’s name?  This seems to be one of those cases of a very very slippery slope being created to solve a real problem but to solve it in the wrong way.

UPDATE – may not be as big a risk to Science as I thought …

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No overselling here – Martin Blaser on the Daily Show discussing Missing Microbes and the human microbiome

Martin Blaser does a good job on the Daily Show discussing the human microbiome and his new book Missing Microbes.

USA Today article on "Your home’s odor may be making you sick"

Quick post – just saw this Tweet from the Airmid Healthgroup

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It points to a story in USA Today that may be of interest – Your home’s odor may be making you sick.  It is about the work on Joan Bennett and researchers from Rutgers and Emory.  I don’t have time to dig into it right now but perhaps others do.

UPDATE 5 minutes later
Oops – posted to the wrong blog. First time I have done this. This was supposed to go to microBEnet. I have posted it there now.

My beloved cat companion Annapurna passed away this AM; I will love and miss her forever

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Well, crap – crap does a crappy job as a treatment sometimes (re: fecal trasnplants and IBD)

Well, this seems like seriously big news in the microbiome world: Fecal Tx Flunks IBD Test but Optimism High.  Charles Bankhead reports on results presented at the “Digestive Disease Week” meeting.  At the meeting Paul Moayyedi from McMaster University reported that a clinical trial of fecal microbial transplants (FMT for short) was stopped midway through the trial due to “lack of efficacy”.  More specifically Bankhead reports

The investigators found no significant differences in the primary outcome or any of the secondary outcomes, which included the Inflammatory Bowel Disease Questionnaire and the EQ5D health status assessment

The researcher seems enthusiastic about FMT still but certainly this means that FMT for IBD is not going to be like FMT for CDiff (just wanted to make sure I got in a lot of abbreviations there).  I am sure there will be much more to come on FMT and it would be good to see more detail on what was presented at the meeting (a paper, or poster, or such).  But for now, this hopefully will temper some of the overselling of FMT that is going around (e.g., Overselling the microbiome award: Mercola/Perlmutter on fecal transplants for severe neurological dysfunction).


Related posts:

Suggestion of the week: Create Project Specific Pages on ImpactStory #AltMetrics

So – I have been doing a little “hacking” of the Impact Story system to create pages specific for individual projects rather than for me or other researchers.  I did this last week for my microBEnet project: Made a project page (hack?) for microBEnet on ImpactStory.  And been playing around with the concept some more.

For example see this page I made for the “iSEEM2: Environmental Niche Atlas” project that is a collaboration between my lab and the lab of Katie Pollard at UCSF (supported by the Gordon and Betty Moore Foundation).  To do this, I registered a new account in ImpactStory (with the first name i and last name SEEM2; using an alternative email address I have). I then used the “upload individual products” and loaded up Pubmed IDs, DOIs, Github web addresses, Slideshare web addresses and more.  And Voila I get I nice page with Altmetrics for our project rather than for myself.

Now I have not loaded everything done on this project yet, but already this is a helpful way to post results from our project and look at some of their metrics. I also updated the website for the project: http://iseem2.wordpress.com.

I think making such project specific pages will end up being useful in many ways. I discovered one this AM in an email I got from Impact Story.  I have appended it below.  Turns out they give weekly updates on how your metrics have changed for that week.  This is the best thing I have seen regarding “Alt Metrics” anywhere.  Very very useful.  Still not sure if this is an “acceptable” use of ImpactStory but I figure they should be OK with it.


Impactstory logo

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user avatari SEEM2impactstory.org/iSEEM2

20+ profile SlideShare downloads

on https://impactstory.org/iSEEM2

One or more of the 31 products on your profile attracted a combined 8 new SlideShare downloads this week, bringing you to 22 total.
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on https://impactstory.org/iSEEM2

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First Delicious bookmarks

on Systematic identification of gene families for use as “markers” for phylogenetic and phylogeny-driven ecological studies of bacteria and archaea and their major subgroups.

This article attracted 1 new Delicious bookmarks this week, bringing it up to 1 total.
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article milestone

First SlideShare downloads

on Phylogeny-Driven Approaches to Genomics and Metagenomics – talk by Jonathan Eisen at Fresno State May 6, 2013

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First SlideShare favorites

on Phylogeny-Driven Approaches to Genomics and Metagenomics – talk by Jonathan Eisen at Fresno State May 6, 2013

This slides attracted 2 new SlideShare favorites this week, bringing it up to 2 total.
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Bad microbiology reporting of the month award: C-Net on IBM "Sequencing the City" meeting

Well, I am still really annoyed by this unbearable article on C-Net yesterday: IBM sees big opportunity in sequencing microbes by Daniel Terdiman.  The article is about this “Sequencing the City” meeting organized by IBM that was on Tuesday and Wednesday.  I talked at the meeting on Tuesday (I could not go on Wednesday).  For more about my talk see: What to do when you realize the meeting you are speaking at is a YAMMM (yet another mostly male meeting)?.  But I am not criticizing the meeting here.  I am criticizing the article in C-Net which has many many flaws. For example consider:

According to James Kaufman, a research manager at the Almaden Research Center, the move to study metagenomics — the study of systems of micro-organisms — came from what he called a tipping point in big data. As more and more government-funded institutions study organisms and bacteria, they’ve collected more information about them, and submitted much of their work to centralized databases. “So there’s a growing library of genomes across the field of life,” Kaufman said. “That made possible metagenomics.”

What?  Metagenomics has been around for a long time.  Sure, many people in the field are taking advantage of so called big data, but there was no “tipping point” needed to launch the field.  This is just completely misguided.
And then even worse

The result: We can now look at and understand whole ecosystems at the bacterial level. One example of how that manifests is what IBM refers to as the Human Microbiome Project. According to an IBM document, that’s about characterizing “microbial communities found at multiple human body sites to discover correlations between changes in the microbiome with changes in human health.”

So – there have been dozens of high profile papers from the Human Microbiome Project.  There are hundreds of web pages with information about the project.  It was started years and years ago.  And the reporter quotes an “IBM document” to tell us what the Human Microbiome Project is?   And even worse the reporter says “what IBM refers to as the Human Microbiome Project” like they ran it / designed it.  Good that they refer to it as the Human Microbiome Project.  You know why?  Because that is what it is known as to all the other $(&@)(* people in the whole (%&# world.

The reporter goes on to write

This kind of work is not entirely new, but the scientists who will be gathering at IBM Research this week are grappling with one conundrum: they don’t know what they don’t know. So a big topic of conversation, and a big part of what IBM would like to see advanced, is “the ability to do metagenomics on the scale of a city or the world….That will depend on software services available in the cloud,” Kaufman said. “It has to be cheap, easy, and accessible from anywhere. That’s what we’re really good at.”

Once again making it seem like IBM is somehow leading this field.  Not to pick on IBM here.  I am glad they organized the meeting.  But either the reporter just got handed a press release from IBM and wrote it up, or did not do any type of background research, or both.  Sure IBM would like to see this.  But so would lots of other people.  Why make this all about IBM?  There are so many people who have done interesting work in the area of “microbiology of the built environment” – why are none of them even discussed?  What exactly is the point of this article if not to simply be a PR piece for IBM?  Aaaaaarg.

UPDATE 5/9 Storify of some of the Tweets about the meeting

Love work of @billgates but "mosquitoes kill more people than people do" is just wrong

I truly love the work Bil Gates and the Gates Foundation have been doing over the last years.  Absolutely wonderful stuff.  But I have a bone (or perhaps a proboscis) to pick with this latest effort: The Deadliest Animal in the World | Bill Gates.  The article discusses some “facts” about how many people different animals kill.  And it uses this to argue for the need for more attention to be placed on mosquitoes.  I agree with the conclusion.  Mosquitoes are a big deal and need much much much more work and attention.  But the data is just, well, not sound.  Here is the problem I have

1. Many of the animals, including mosquitoes, are on the list are there because of the diseases they transmit.  For example, dogs are there (for rabies), and tsetse flies are there for sleeping sickness.  That is, they do not kill people directly but indirectly because of a disease they transmit.

2. If we follow that logic, which I am fine with, then we need to add a whole lot of deaths to the “human” column.  After all, humans transmit a whole heck of a lot of diseases that kill humans.  One source I found has the following #s

  • HIV/AIDS: 1.78 million per year
  • Tuberculosis: 1.34 million per year
  • Flu: 250-500,000 per year
  • HAIs: >100,000
  • Syphilis: 100,000
  • Measles: 600,000

and many many many more.   The totals are probably greater than 5 million per year that are killed by infectious diseases where it was humans who transmitted the agent to other humans.  Way more than the mosquitoes.  Again, I agree with the conclusion.  We need lots more attention on mosquitoes.  But there seems little doubt to me which animal is most responsible for the spread of deadly pathogens to humans.  And that animal is us.


UPDATE 5/3

Am kind of annoyed at the press coverage of this Gates – mosquitoes are the deadliest animal – concept.  Here are some examples where people just ate up the idea without really asking any questions about its accuracy

And many many more.  It is a cute concept.  And an important one.  It just happens to be wrong.


UPDATE 5/4. Some Tweets of relevance

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UPDATE 5/5
See Vox post: No, mosquitoes aren’t deadlier than humans

Also see these posts which run with the Gates meme

UPDATE 5/6