Today at 4 at #UCDavis: Jonathan Pritchard on “Interpreting functional consequences of human genetic variation”

Jonathan Pritchard is will be giving the Ecology and Evolution seminar today on “Interpreting functional consequences of human genetic variation.”4:10-5:30PM; in 176 Everson Hall.

Jonathan’s work addresses basic questions in evolutionary biology and genomics using computational and statistical approaches.

From his website:
“Much of our work focuses on questions relating to genetic variation and evolution. What can we learn from DNA sequence data about population structure, population histories and natural selection? How does genetic variation impact phenotypic traits, both at the organismal and cellular level (including an emphasis on gene regulation)? ”
http://pritchardlab.stanford.edu/home.html

Right to be forgotten bill has grave implications for science

Yes, the web can be a quagmire of inaccurate, offensive libelous crap.  But wow – this new ruling about the “right to be forgotten bill” in Europe I think goes too far (e.g., see this story for more info on the bill Google gets ‘right to be forgotten’ requests hours after EU ruling – Telegraph).  (Quick summary – the ruling basically says that people have the right to request that search engines make it impossible to access   certain links – such as ones to stories the requestor does not like).

I am particularly concerned about how this bill will affect scientific discourse.  Suppose for example that Andrew Wakefield wants criticism of his fraduelent work on vaccines to be expunged from the links that come up in Google searches?  What should Google do there?  What about retracted papers in general?  What is the person behind the paper does not think that retracted papers should appear in searches for that person’s name?  This seems to be one of those cases of a very very slippery slope being created to solve a real problem but to solve it in the wrong way.

UPDATE – may not be as big a risk to Science as I thought …

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No overselling here – Martin Blaser on the Daily Show discussing Missing Microbes and the human microbiome

Martin Blaser does a good job on the Daily Show discussing the human microbiome and his new book Missing Microbes.

USA Today article on "Your home’s odor may be making you sick"

Quick post – just saw this Tweet from the Airmid Healthgroup

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It points to a story in USA Today that may be of interest – Your home’s odor may be making you sick.  It is about the work on Joan Bennett and researchers from Rutgers and Emory.  I don’t have time to dig into it right now but perhaps others do.

UPDATE 5 minutes later
Oops – posted to the wrong blog. First time I have done this. This was supposed to go to microBEnet. I have posted it there now.

My beloved cat companion Annapurna passed away this AM; I will love and miss her forever

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Well, crap – crap does a crappy job as a treatment sometimes (re: fecal trasnplants and IBD)

Well, this seems like seriously big news in the microbiome world: Fecal Tx Flunks IBD Test but Optimism High.  Charles Bankhead reports on results presented at the “Digestive Disease Week” meeting.  At the meeting Paul Moayyedi from McMaster University reported that a clinical trial of fecal microbial transplants (FMT for short) was stopped midway through the trial due to “lack of efficacy”.  More specifically Bankhead reports

The investigators found no significant differences in the primary outcome or any of the secondary outcomes, which included the Inflammatory Bowel Disease Questionnaire and the EQ5D health status assessment

The researcher seems enthusiastic about FMT still but certainly this means that FMT for IBD is not going to be like FMT for CDiff (just wanted to make sure I got in a lot of abbreviations there).  I am sure there will be much more to come on FMT and it would be good to see more detail on what was presented at the meeting (a paper, or poster, or such).  But for now, this hopefully will temper some of the overselling of FMT that is going around (e.g., Overselling the microbiome award: Mercola/Perlmutter on fecal transplants for severe neurological dysfunction).


Related posts:

Suggestion of the week: Create Project Specific Pages on ImpactStory #AltMetrics

So – I have been doing a little “hacking” of the Impact Story system to create pages specific for individual projects rather than for me or other researchers.  I did this last week for my microBEnet project: Made a project page (hack?) for microBEnet on ImpactStory.  And been playing around with the concept some more.

For example see this page I made for the “iSEEM2: Environmental Niche Atlas” project that is a collaboration between my lab and the lab of Katie Pollard at UCSF (supported by the Gordon and Betty Moore Foundation).  To do this, I registered a new account in ImpactStory (with the first name i and last name SEEM2; using an alternative email address I have). I then used the “upload individual products” and loaded up Pubmed IDs, DOIs, Github web addresses, Slideshare web addresses and more.  And Voila I get I nice page with Altmetrics for our project rather than for myself.

Now I have not loaded everything done on this project yet, but already this is a helpful way to post results from our project and look at some of their metrics. I also updated the website for the project: http://iseem2.wordpress.com.

I think making such project specific pages will end up being useful in many ways. I discovered one this AM in an email I got from Impact Story.  I have appended it below.  Turns out they give weekly updates on how your metrics have changed for that week.  This is the best thing I have seen regarding “Alt Metrics” anywhere.  Very very useful.  Still not sure if this is an “acceptable” use of ImpactStory but I figure they should be OK with it.


Impactstory logo

Your new research impacts this week

user avatari SEEM2impactstory.org/iSEEM2

20+ profile SlideShare downloads

on https://impactstory.org/iSEEM2

One or more of the 31 products on your profile attracted a combined 8 new SlideShare downloads this week, bringing you to 22 total.
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on https://impactstory.org/iSEEM2

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That brings this article up to 29 Scopus citations total.
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First Delicious bookmarks

on Systematic identification of gene families for use as “markers” for phylogenetic and phylogeny-driven ecological studies of bacteria and archaea and their major subgroups.

This article attracted 1 new Delicious bookmarks this week, bringing it up to 1 total.
It marks your 4th unique product to get a bookmarks on Delicious. Nice work!
article milestone

First SlideShare downloads

on Phylogeny-Driven Approaches to Genomics and Metagenomics – talk by Jonathan Eisen at Fresno State May 6, 2013

This slides attracted 7 new SlideShare downloads this week, bringing it up to 7 total.
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First SlideShare favorites

on Phylogeny-Driven Approaches to Genomics and Metagenomics – talk by Jonathan Eisen at Fresno State May 6, 2013

This slides attracted 2 new SlideShare favorites this week, bringing it up to 2 total.
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Bad microbiology reporting of the month award: C-Net on IBM "Sequencing the City" meeting

Well, I am still really annoyed by this unbearable article on C-Net yesterday: IBM sees big opportunity in sequencing microbes by Daniel Terdiman.  The article is about this “Sequencing the City” meeting organized by IBM that was on Tuesday and Wednesday.  I talked at the meeting on Tuesday (I could not go on Wednesday).  For more about my talk see: What to do when you realize the meeting you are speaking at is a YAMMM (yet another mostly male meeting)?.  But I am not criticizing the meeting here.  I am criticizing the article in C-Net which has many many flaws. For example consider:

According to James Kaufman, a research manager at the Almaden Research Center, the move to study metagenomics — the study of systems of micro-organisms — came from what he called a tipping point in big data. As more and more government-funded institutions study organisms and bacteria, they’ve collected more information about them, and submitted much of their work to centralized databases. “So there’s a growing library of genomes across the field of life,” Kaufman said. “That made possible metagenomics.”

What?  Metagenomics has been around for a long time.  Sure, many people in the field are taking advantage of so called big data, but there was no “tipping point” needed to launch the field.  This is just completely misguided.
And then even worse

The result: We can now look at and understand whole ecosystems at the bacterial level. One example of how that manifests is what IBM refers to as the Human Microbiome Project. According to an IBM document, that’s about characterizing “microbial communities found at multiple human body sites to discover correlations between changes in the microbiome with changes in human health.”

So – there have been dozens of high profile papers from the Human Microbiome Project.  There are hundreds of web pages with information about the project.  It was started years and years ago.  And the reporter quotes an “IBM document” to tell us what the Human Microbiome Project is?   And even worse the reporter says “what IBM refers to as the Human Microbiome Project” like they ran it / designed it.  Good that they refer to it as the Human Microbiome Project.  You know why?  Because that is what it is known as to all the other $(&@)(* people in the whole (%&# world.

The reporter goes on to write

This kind of work is not entirely new, but the scientists who will be gathering at IBM Research this week are grappling with one conundrum: they don’t know what they don’t know. So a big topic of conversation, and a big part of what IBM would like to see advanced, is “the ability to do metagenomics on the scale of a city or the world….That will depend on software services available in the cloud,” Kaufman said. “It has to be cheap, easy, and accessible from anywhere. That’s what we’re really good at.”

Once again making it seem like IBM is somehow leading this field.  Not to pick on IBM here.  I am glad they organized the meeting.  But either the reporter just got handed a press release from IBM and wrote it up, or did not do any type of background research, or both.  Sure IBM would like to see this.  But so would lots of other people.  Why make this all about IBM?  There are so many people who have done interesting work in the area of “microbiology of the built environment” – why are none of them even discussed?  What exactly is the point of this article if not to simply be a PR piece for IBM?  Aaaaaarg.

UPDATE 5/9 Storify of some of the Tweets about the meeting

Love work of @billgates but "mosquitoes kill more people than people do" is just wrong

I truly love the work Bil Gates and the Gates Foundation have been doing over the last years.  Absolutely wonderful stuff.  But I have a bone (or perhaps a proboscis) to pick with this latest effort: The Deadliest Animal in the World | Bill Gates.  The article discusses some “facts” about how many people different animals kill.  And it uses this to argue for the need for more attention to be placed on mosquitoes.  I agree with the conclusion.  Mosquitoes are a big deal and need much much much more work and attention.  But the data is just, well, not sound.  Here is the problem I have

1. Many of the animals, including mosquitoes, are on the list are there because of the diseases they transmit.  For example, dogs are there (for rabies), and tsetse flies are there for sleeping sickness.  That is, they do not kill people directly but indirectly because of a disease they transmit.

2. If we follow that logic, which I am fine with, then we need to add a whole lot of deaths to the “human” column.  After all, humans transmit a whole heck of a lot of diseases that kill humans.  One source I found has the following #s

  • HIV/AIDS: 1.78 million per year
  • Tuberculosis: 1.34 million per year
  • Flu: 250-500,000 per year
  • HAIs: >100,000
  • Syphilis: 100,000
  • Measles: 600,000

and many many many more.   The totals are probably greater than 5 million per year that are killed by infectious diseases where it was humans who transmitted the agent to other humans.  Way more than the mosquitoes.  Again, I agree with the conclusion.  We need lots more attention on mosquitoes.  But there seems little doubt to me which animal is most responsible for the spread of deadly pathogens to humans.  And that animal is us.


UPDATE 5/3

Am kind of annoyed at the press coverage of this Gates – mosquitoes are the deadliest animal – concept.  Here are some examples where people just ate up the idea without really asking any questions about its accuracy

And many many more.  It is a cute concept.  And an important one.  It just happens to be wrong.


UPDATE 5/4. Some Tweets of relevance

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UPDATE 5/5
See Vox post: No, mosquitoes aren’t deadlier than humans

Also see these posts which run with the Gates meme

UPDATE 5/6

What to do when you realize the meeting you are speaking at is a YAMMM (yet another mostly male meeting)?

I am supposed to be talking at a meeting Tuesday: Almaden Institute 2014: Sequence the City -Metagenomics in the Era of Big Data.

In looking at the agenda for the meeting I am pretty bummed about the gender ratio of speakers. Looks like 18:5 Men to Women. 

  • Jeff Welser IBM 
  • David Haussler UCSC 
  • Daniel Huson Tubingen U 
  • Joe DeRisi UCSF 
  • Jane Carlton NYU 
  • Ajay Royyuru IBM 
  • Paula Olsiewski Sloan Foundation 
  • Christopher Mentzel Moore Foundation 
  • Anne Marie Kimball Gates Foundation 
  • Jonathan Eisen UC Davis 
  • Jessica Green U Oregon 
  • Mark Adams JCVI 
  • Eric Alm MIT 
  • Raul Andino UCSF 
  • Scott Kahn Illumina 
  • Mike Lelivelt Ion Torrent 
  • Radoje (Rade) Drmanac Complete Genomics 
  • Brett Bowman Pacific Biosciences 
  • Chris Mason Cornell 
  • Bart Weimer UC Davis 
  • David Crean Mars 
  • Astri Wayadande Oklahoma State U 
  • Christopher Elkins FDA

Not sure what to do about this. I am certainly (in a few minutes) going to be writing to the organizers. I am also pondering cancelling talking. I try very hard to be vigilant about gender ratios at meetings and it drives me crazy to see such skews. I know it is not always possible to have meetings have equal representation and I know some people try very hard and do not succeed. But this seems unpleasantly extreme. So – any thoughts or recommendations as to what to do would be appreciated.


UPDATE 5/5 –


Well the schedule has been updated – and now the male: female speaker ratio is 21:6. Note – Jack Gilbert is moderating and speaking and I am counting him twice. Also Robert Prill is opening each day and closing day 2 so in a way this could be counted as 23:6.

  • Robert Prill, IBM 
  • Jeff Welser IBM 
  • David Haussler UCSC 
  • Daniel Huson Tubingen U 
  • Joe DeRisi UCSF 
  • Jane Carlton NYU 
  • Ajay Royyuru IBM 
  • Laurie Garrett (moderating) 
  • Paula Olsiewski Sloan Foundation 
  • Christopher Mentzel, Moore Foundation 
  • Anne Marie Kimball Gates Foundation 
  • Jonathan Eisen UC Davis 
  • Jessica Green U Oregon 
  • Robert Prill 
  • Mark Adams JCVI 
  • Eric Alm MIT 
  • Raul Andino UCSF 
  • Jack Gilbert (moderating) 
  • Jack Gilbert (speaking) 
  • Scott Kahn, Illumina 
  • Mike Lelivelt Ion Torrent 
  • Radoje (Rade) Drmanac Complete Genomics 
  • Brett Bowman Pacific Biosciences 
  • Chris Mason Cornell 
  • Bart Weimer UC Davis 
  • David Crean Mars 
  • Astri Wayadande Oklahoma State U 
  • Christopher Elkins FDA 
  • Robert Prill

UPDATE 5/7

So I decided to go to the meeting and talk. Here is a video slideshow of my talk with audio.

 and here are the slides on Slideshare

I am not sure if I made the right decision but what I decided to do was to change my talk to feature the work of women and to highlight those women.


UPDATE 5/8

Here are some pics showing the before (left) and after (right) for how I changed my talk from the previous talk I gave about this topic.  Among the changes I made:

  • I added names and pictures of the women behind the work 
  • Changed examples to be about work of women when I had been using work of men
  • Added additional examples of work by women directly related to my talk
And I used the pictures and names on the slides to remind me to talk about the women behind the work. 

I think this strategy is a potentially useful tool in combatting the implicit and subtle biases against women in STEM fields.  All of what I said was true.  I just made sure to emphasize and use examples of work by women when previously I had either not said who did certain work or had sometimes emphasized work by men.  And I made sure to show pictures and say the names of the women behind the work too.

Added name and picture of program officer Paula Olsiweski who I had quoted previously.
Changed example of new publication that we add to our collection and used a publication
by a female graduate student, post doc Rachel Adams.  
Included name and picture of student post-doc Rachel Adams on other slides
about the topic

Included name and picture of student post-doc Rachel Adams on other slides
about the topic. 

Added a mention of the blog post by student post-doc Rachel Adams.

Added picture and name of post doc Allison Fish who organized meeting
I was discussing.

Added name and picture of Mary Jo Seminoff who coordinates
production of the newsletter I had mentioned.

Added screenshot and names of Holly Bik interviewing Amy Pruden for the
“People Behind the Science” series mentioned in previous slide.

Added name and picture of Brooke Borel and discussed her news stories (had mentioned
news stories in general w/o examples)

Added picture and name and blog post of Holly Ganz who wrote about
the news stories by Brooke Borel.

Changed example to be about Maria Gloria Dominguez-Bello instead
of Thomas Bruns.

Changed example to be about Maria Gloria Dominguez-Bello instead
of Thomas Bruns.

Added extra slide discussing Software Carpentry workshop
organized by Jenna Lang and Tracy Teal (and added
names and pics of them).

Added pics and names of Jo Handelsman and Tiffany Tsang who coordinated
one of the examples on the slide but who had not gotten mentioned
specifically.

Added picture and name of undergraduate student Hannah Holland-Moritz who was
involved in this work.

Added picture and name of research associate Madison Dunitz
who led this work.

Added name and picture of undergraduate student Sabreen Aulakh
who was involved in this work.

Added picture of graduate student Laura Sauder who
was our main contact in the lab of Josh Newfeld.

Added pictures and names of Darlene Cavalier and Caren Cooper who
inspired me to get involved in Citizen Science.

Added picture and name of Darlene Cavalier who was keynote speaker
at these meetings.

Added extra slide on the phone microbiome project and added names and pics of the people
involved including graduate student Georgia Barguil.

Added names and pics of the people behind this project (Holly Menninger and Rob Dunn)

Changed slide a little bit and added name and pic of Jessica Richman, one of the people behind the uBiome project.

Added pics that included more of the key women behind this project – including Darlene Cavalier, Wendy Brown
and Jenna Lang.

Added a slide about Altmetrics and added pic and name of Heather Piwowar and mentioned
her work  Had included one line about Altmetrics on a slide before.

Added reference to paper by Holly Bik and Miriam Goldstein and
emphasized the workshops run by Holly Bik.  Included pics and names on slide too.

UPDATE 5/8

Added links to find out more information about the work of the women in the slides (links are in the image captions).
UPDATE 9/6/14 https://apis.google.com/js/plusone.js